lupus nephritis
Conditions
Interventions
MSCs infusion group:On the basis of conventional doses of corticosteroids + immunosuppressive agents, four 1*10^7/Kg UC MSCs (first, seventh, and six months after the first and seventh days) were admi
control group:Routine dose of glucocorticoid + immunosuppressive agent
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: SLE patients met the following criteria: 1. meet the American College of Rheumatology 1997 revised SLE classification diagnostic criteria, aged 16~70 years old; 2. lupus nephritis (LN), urine protein (24h) = 1000mg/24h; 3. dimensional prednisone = 20mg/d; cyclophosphamide (CTX); 4. CTX total cumulative amount of invalid 8~10g refers to patients before a recent treatment (12~18 months) accumulation, or other immunosuppressive agents (cyclosporine A, azathioprine, mycophenolate mofetil etc) is invalid for 3 months.
Exclusion criteria
Exclusion criteria: The patient had an infection that was not controlled; the patient had one or more organ failure; pregnancy or breast feeding; rejected mesenchymal stem cell transplantation; could not be followed up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24H urinary protein quantitation;WBC;PLT;creatinine;SLEDAI score; | — |
Countries
China
Contacts
Public ContactQi Wufang
Tianjin First Central Hospital
Outcome results
None listed