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The efficacy of berberine and metformin on polycystic ovary syndrome with metabolic disorders: a randomized controlled study.

The efficacy of berberine and metformin on polycystic ovary syndrome with metabolic disorders: a randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17011656
Enrollment
Unknown
Registered
2017-06-14
Start date
2017-06-12
Completion date
Unknown
Last updated
2020-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome

Interventions

experimental group:Berberine 0.4 tid, 6 months
Control:Metformin 0.5 tid, 6 months

Sponsors

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1) Diagnosis of PCOS; 2) Aged 18-40 years; 3) BMI >= 23 kg/m2?Waist circumstance >= 85cm; 4) Diagnosis of IGT(impaired glucose tolerance); 5) No pregnancy plan during the treatment.

Exclusion criteria

Exclusion criteria: 1) Pregnancy or lactation; 2) Administration of drugs regulating glucose or microbiota in the last 3 months.

Design outcomes

Primary

MeasureTime frame
OGTT 2-hour glucose;—

Secondary

MeasureTime frame
BMI;WHR;SBP;DBP;PRL;FSH;LH;E2;TT;FT;SHBG;A2;DHEAS;FPG;FIN;HOMA-IR;AUCINS;HbA1C;TC;TG;HDL-C;LDL-C;—

Countries

China

Contacts

Public ContactLi Lin

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

lilinsums@163.com+86 13434184260

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026