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The change of cytokines, oxidative stress, and Matrix Metallo Proteinase between total intravenous anesthesia and Desflurane anesthesia

The change of cytokines, oxidative stress, and Matrix Metallo Proteinase between total intravenous anesthesia and Desflurane anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17011600
Enrollment
Unknown
Registered
2017-06-09
Start date
2012-04-01
Completion date
Unknown
Last updated
2017-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver transplantation

Interventions

TIVA group:TIVA with propofol
DES group:desflurane anesthesia

Sponsors

Tri-Service General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
31 Years to 67 Years

Inclusion criteria

Inclusion criteria: 50 living donor LT recipients were enrolled from April 2012 to July 2013.

Exclusion criteria

Exclusion criteria: Recipients were excluded if they met any of the following criteria: presence of sepsis, shock, hepatoencephalopathy, hepatorenal syndrome, or massive pleural effusion, requirements for pre-transplant endotracheal intubation with mechanical ventilation, or use of vasopressors before transplantation, and any contraindication to fentanyl, propofol, or desflurane.

Design outcomes

Primary

MeasureTime frame
ICU stay;days in hospital;cytokines;heme oxygenase-1 (HO-1);matrix metalloproteinase-9 (MMP-9);—

Secondary

MeasureTime frame
alanine aminotransferase (ALT) concentration at 24 hours after transplantation;time to normal international normalized ratio (INR) of prothrombin time (PT);The Sequential Organ Failure Assessment (SOFA) score;—

Countries

China

Contacts

Public ContactZhi-Fu Wu

Tri-Service General Hospital

aneswu@gmail.com+886-975978215

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026