knee osteoartritis
Conditions
Interventions
group A:No use of TXA and dexamethasone before and after surgery
group B:Single bolus of 20mg/kg TXA and 20mg dexamethasone before surgery
group C:A bolus of 20mg/kg TXA before surgery, another bolus of 1 g TXA 3, 7, 12, 18, 24 hours later, no use of dexamethasone
group D:A bolus of 20mg/kg TXA and 20mg dexamethasone before surgery, another bolus of 1 g TXA 3, 7, 12, 18, 24 hours later and another bolus of 10 mg dexamethasone 24, 48 hours later
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Primary unilateral total knee artropasty; (2) Patients with knee osteoartritis; (3) Normal platelet and coagulation function preoperatively; (4) Normal intravenous ultrasound in the lower extremities preoperatively; (5) Able and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Systemic infections such as pulmonary infection or urinary tract infection are not controlled preoperatively; (2) Abnormal immune function or combined immune-related disease preoperatively; (3) Abnormal inflammatory index preoperatively (C-reactive protein >20 mg/L); (4) Abnormal fibrinolysis index preoperatively (FDP > 5mg/L); (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) Allergy to tranexamic acid (TXA) or dexamethasone or have contraindications; (7) Patients at high risk of thrombosis; (8) History of deep vein thrombosis (VTE, calf muscle vein thrombosis or superficial vein thrombosis, pulmonary embolism); (9) serious liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fibrinolysis index (D-Dimer, FDP);inflammatory index(CRP, IL-1ß, IL-6, TNF-a);immune index (CD3, CD4, CD8, complement C3 and C4); | — |
Secondary
| Measure | Time frame |
|---|---|
| blood loss;Hb drop;transfusion;VAS pain score;opioid consumption;Knee circumference;Range of motion;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactFuxing Pei
West China Hospital, Sichuan University
Outcome results
None listed