Primary Sjogren 's syndrome
Conditions
Interventions
Experimental group:Metformin 250mg 3 times / day
atorvastatin tablets 10mg 1 time / day
Control:Traditional DMARDs
Sponsors
Inner Mongolia University of Science and Technology Baotou Medical College First Affiliated Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. aged 18 to 65 years old, men and women are not limited; 2. in line with the 2002 international classification of primary Sjogren's syndrome (diagnostic) standards 3. Screening of subjects must meet the following laboratory tests: Hb 85g/L; WBC 3*10^9/L; neutrophils 1.5*10^9/L; platelets 100*10^9/L; 2 transaminase normal upper limit of 2 times; creatinine 120mol/L (1.4 Mg/dl); 4. Th17 is higher than the normal range or Treg decrease or Th17 / Treg ratio imbalance; 5. Pregnancy tests for women of childbearing age were negative and agreed to take effective contraceptive measures during the trial period and within 6 months after the end of the trial; 6. screening subjects subject to body mass index (BMI) 20; 7. subjects can be regularly referral.
Exclusion criteria
Exclusion criteria: (1) disabled, bed rest, wheelchair dependent, life can not take care of themselves; (2) combined with other rheumatic diseases; (3) screening within 5 years before or now suffering from malignant tumors; (4) subjects with severe acute, chronic or recurrent infections (eg pneumonia or pyelonephritis, recurrent pneumonia, chronic bronchiectasis, tuberculosis, etc.); (5) suffering from active hepatitis or a history of hepatitis C; (6) HIV infection; (7) such as lymphoma and other lymphoproliferative diseases; (8) multiple sclerosis or other central nervous demyelinating disease; had or now suffering from congestive heart failure; (9) have serious, progressive, uncontrolled liver, kidney, blood, gastrointestinal tract, endocrine, heart, lung, nerve and brain diseases; (10) Doctors evaluate that patients are not fit to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms;Pathology of the labial gland;ANA;SS-A;SS-B;IgG;IgA;IgM;ESR;CRP;Th17;Treg;ESSDAI score.;Peripheral blood cell count;liver function;Renal function;blood sugar;Blood lipids;Myocardial enzymes; | — |
Countries
China
Contacts
Public ContactWang Yongfu
Inner Mongolia University of Science and Technology Baotou Medical College First Affiliated Hospital
Outcome results
None listed