Intracranial hemorrhage
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 years old and more; (2) At least 6h after onset; (3) Acute stroke syndrome due to spontaneous intracranial haemorrhage(sICH)confirmed by CT or MRI scan; (4) GCS > 5; (5) At least two systolic blood pressure(BP) measurements of =150 mmHg and = 220mmHg, record = 5min apart; (6) Meet the indication of surgery and receive the surgery within 24h after ictus of ICH; (7) Agree to participate in this clinic trail and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Known definite indication to antihypertensive treatment (e.g. very high systolic blood pressure N220 mm Hg; hypertensive encephalopathy; aortic dissection); known definite contraindication to antihypertensive treatment (e.g. the high blood pressure is caused by the increasing of the intracranial pressure which is called Cushing reaction; severe cerebral or carotid stenosis, severe renal failure); (2) The intracerebral hemorrhage is caused by secondary; factors (e.g. arteriovenous malformation; Moya Moya disease; anticoagulant correlation hemorrhage; tumor stroke); (3) Hematoma enlarges and meets the indication of surgery during hospitalization; (4) Known definite contraindication to operation; (5) History of ischemic stroke; (6) Known advanced dementia or disability (e.g. paralyze, aphasia) before ICH happens; (7) Concomitant medical illness that would interfere with outcome assessments and follow-up (e.g. advanced cancer; severe cardiovascular disease).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| combined endpoin tof death and dependence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Health related quality of life index;incidence of rebleeding;incidence of ischemic stroke; | — |
Countries
China
Contacts
Public ContactYou Chao
West China Hospital, Sichuan University
Outcome results
None listed