colon/rectal cancer, breast cancer
Conditions
Interventions
group R:0.2% ropivacaine (PCEA)
group M:morphine (0.5mg/mL, PCIA)
group N:Nalbuphine (1mg/mL, PCIA)
group S:sufentanil (1ug/mL, PCIA)
group F:2mg/mL flurbiprofen axetil combined with 0.8ug/mLsufentanil (PCIA)
Sponsors
Chongqing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Colorectal cancer patients scheduled undergo elective laparoscopic radical operation or breast cancer patients scheduled undergo elective unilateral modified radical mastectomy will be enrolled. The inclusion criteria: 1) Aged 18 to 75 years; 2) With New York heart association (NYHA)functional class I and II; 3) Biochemical examination CRE<176umol/L.
Exclusion criteria
Exclusion criteria: Patients with any of the following conditions should be excluded in this study 1. History of chronic pain; 2. History of stroke, mental disorder,epilepsy, Parkinson's disease or MMSE11.1mmol/L); (2) Within one month of acute myocardial infarction; (3) With New York heart association (NYHA) functional class above III. 7. Cognitive dysfuntion or unable to communicate accurately; 8. Patients who refused to take part in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| numerical rating scale;Hospital Anxiety and Depression Scale;cortisol;the number of natural killer cell;Th1/Th2 cytokines;incidence of chronic postsurgical pain;adrenocorticotrophic hormone;Confusion Assessment Method for the Intensive Care Unit, CAM-ICU;Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| ID Pain questionnaire;Ramsay sedation score;mini-mental status examination, MMSE;Richmond Agitation Sedation Scale, RASS; | — |
Countries
China
Contacts
Public ContactLiu Hongliang
Chongqing Cancer Hospital
Outcome results
None listed