colorectal cancer
Conditions
Interventions
two:SBRT
Sponsors
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Biopsy proven unresectable mCRC (Stage IV); (2) Primary resection of CRC; (3) 1 to 3 liver metastases with an individual maximum diameter of up to 5 cm; (4) Absence of evidence of extra-hepatic disease; (5) Metastatic liver lesions reveiving R0 or R1 resection or radiofrequency ablation; (6) Presence of tumor bed; (7) ECOG PS 0-1; (8) Aged 18-70 years; (9) Patients should have adequate bone marrow function as defined by peripheral granulocyte count of =1500/mm3; (10) AST, ALT & Alkaline phosphates must be = 2.5X the upper limit of normal. Total bilirubin must be within the limit of normal; (11) Patients must provide verbal and written informed consent to participate in the study; (12) Absence of any severe pulmonary or cardiac diseases.
Exclusion criteria
Exclusion criteria: (1) Patients with either untreated brain metastases or brain metastases treated within the past three months are ineligible; (2) Patients who are pregnant; (3) Patients with severe organ dysfunction; (4) History of abdominal radiotherapy; (5) Unwillingness to participate or inability to comply with the protocol for the duration of the study; (6) Participation in any investigational drug study within 3 months preceding the start of study treatment; (7) Patients not suitable to take part in clinical trials judged by researches.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| intrahepatic DFS;OS; | — |
Countries
China
Contacts
Public ContactTao Zhang
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed