Constipation
Conditions
Interventions
Group 1:ZhiShi 10g, BaiZhu 30g
Group 2:ZhiShi 10g, BaiZhu 50g
Group 3:ZhiShi 10g, BaiZhu 70g
Control Group:Prucalopride Succinate Tablets
Sponsors
The Affiliated Hospital of Nanjing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) in line with the slow transit type of functional constipation in Western diagnostic criteria and diagnostic criteria for traditional Chinese medicine constipation; (2) between 60 and 85 years of age; (3) with the treatment, can be asked in detail about the patient's history and fill in the history of the score scale. Excluding the history of intestinal or systemic organic disease, intestinal endoscopy and other auxiliary examination prompted organic disease, taking special drugs caused by constipation, breathing, digestion, circulation, blood, endocrine system serious diseases, liver and kidney function Obviously abnormal; (4) the last other treatment time and the study of treatment interval> 1 month; (5) All participants in clinical studies should agree that any food and drugs that cause a corresponding effect on gastrointestinal motility can not be used during clinical studies; (6) individuals agree to receive treatment and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) do not agree to participate in the study; (2) allergies or allergic reactions to drugs in this trial; (3) poor compliance, can not cooperate with the treatment or half-way out; (4) have severe liver and kidney dysfunction and cardiovascular, kidney, hematopoietic system, malignant tumor serious primary disease, diabetes, hyperthyroidism and other metabolic diseases and mental patients; (5) within 1 month before treatment or served during the treatment of other drugs to take defecation; (6) by colonoscopy or lower gastrointestinal examination confirmed rectum, colon organic disease (such as cancer, Crohn's disease, colon polyps, intestinal tuberculosis, etc.) caused by intestinal stenosis or abdominal surgery history ; (7) combined with export obstructive constipation or irritable bowel syndrome; (8) does not meet the inclusion criteria, not in accordance with the provisions of medication, can not determine the efficacy or incomplete information, affect the efficacy or safety judgment; (9) suspected or indeed alcohol, drug abuse history. Or other factors such as the possibility of reducing the likelihood of group entry or complicating the group, such as frequent changes in the working environment, etc., (10) Patients who are unable to obtain their full informed consent due to cognitive impairment or health status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First defecation time after taking medcine;Stool form scale;Cleveland Constipation Score, CCS;Patient Assessment of Constipation-Quality of Life, PAC-QOL; | — |
Countries
China
Contacts
Public ContactWang Hao
The Affiliated Hospital of Nanjing University of Chinese Medicine
Outcome results
None listed