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The comparative study of topical administration of tranexamic acid plus cocktail analgesic and cocktail analgesic for reducing blood loss during total knee arthroplasty

The comparative study of topical administration of tranexamic acid plus cocktail analgesic and cocktail analgesic for reducing blood loss during total knee arthroplasty

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17010826
Enrollment
Unknown
Registered
2017-03-09
Start date
2015-08-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

topical administration of cocktail analgesic:topical administration of cocktail analgesic
topical administration of tranexamic acid plus cocktail analgesic:topical administration of tranexamic acid plus cocktail analgesic

Sponsors

Department of orthopedics, Xinqiao Hospital, Third Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) patients who underwent unilateral TKA operation for the first time and the age of >50 years old with osteoarthritis; (2) preoperative hemoglobin (Hb) and blood coagulation function were normal; (3) there was no abnormality in the lower extremity venous color Doppler ultrasound.

Exclusion criteria

Exclusion criteria: (1) preoperative anemia (Hb 1.4), activated partial thromboplastin time (APTT) >1.4 times the normal value; (5) allergic to tranexamic acid; (6) serious heart, lung, liver renal insufficiency.

Design outcomes

Primary

MeasureTime frame
Intraoperative blood loss;Drainage volume;hemoglobin;Hematocrit;—

Countries

China

Contacts

Public ContactHe Zhichao

Department of orthopedics, Xinqiao Hospital, Third Military Medical University

546011787@qq.com+86 18658005827

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026