lumber spine degeneration disease and lumbar vertebral fracture
Conditions
Interventions
treatment group:using enriched bone marrow stem cells recombinating parous biomaterial for implantation
controlled group:autologous bone transplantation
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged from 18 to 65 years, male and female; (2) Two or three segmental lumber spine disease requiring decompression surgery and intervertebral fusion; (3) No admission for other clinical study in recent three months; (4) No acute infection,mental disorder and calcification metabolic disorders; (5) Be willing to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) pathological fracture caused by osteopathy such as benign or malignant tumor; (2) acute or severe infection or chronic infection in its active phase; (3) osteoporosis,lacking critical bone in fracture site or comminuted fracture; (4) metabolic disorders,immune dysfunction or drug abuse; (5) accompanied of cardiac,lung,liver,kidney,hemopoietic system or endocrine system disease; (6) be allergic to implants or various medicine; (7) pregnant woman or lactating women; (8) patients unwilling or cannot limit activities or follow medical advice; (9) too weak to evaluate the security and validity of implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fusion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| JOA score;intervertebral space height;enrichment rate of stem cells; | — |
Countries
China
Contacts
Public ContactJie Zhao
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed