lymphoma
Conditions
Interventions
experiment group:zoledronic acid,oral vitamin D and calcium
control group:oral vitamin D and calcium
Sponsors
Caner center,West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed lymphomas; 2. Aged 20 years or older; 3. Chemotherapy regimens include high dose glucocorticoid; 4. Creatinine clearance=2 upper limit of normal; 5. High dose glucocorticoid:dexamethasone >20mg/d,prednisone>60mg/d,methylprednisolone>75mg/d; 6. Signed informed consent documents.
Exclusion criteria
Exclusion criteria: 1. bone metastasis; 2. inhibition in the spinal cord cause by collapse; 3. Bisphosphonate used in 6 months; 4. primary hyperparathyroidism; 5. Osteomalasia; 6. Untreated hypocalcemia (ionized, iCa), before enrollment calcium levels must be within the normal range; 7. Untreated secondary hyperparathyroidism, as long as the patient in the treatment, parathyroid hormone (PTH) abnormalities can also be grouped; 8. Patients with vitamin D deficiency ( 10.2 mg / dL or ionized calcium> 1.32 mmol/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone Mineral Density;25-(OH)D3;CTX;bALP; | — |
Countries
China
Contacts
Public ContactLiqun Zou
West China Hospital of Sichuan University
Outcome results
None listed