breast cancer
Conditions
Interventions
Experiemental group 1:neoadjuvant chemotherapy and B model with low mechanical index
Experiemental group 2:neoadjuvant chemotherapy and B model with high mechanical index
Experiemental group 3:neoadjuvant chemotherapy and VFlash model with low mechanical index
Experiemental group 4:neoadjuvant chemotherapy and VFlash model with high mechanical index
Sponsors
Xinqiao Hospital, Third Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Pathologically confirmed breast cancer; (2) Female,aged 18 to 75 years; (3) Single acoustic accessible lesion evaluated by Ultrasound, Computed Tomography(CT) or Magnetic Resonance Imaging(MRI); (4) Expected survival time=5 months; Performance Status(PS) 0-2; (5) Blood routine examination: WBC=3.5?10^9/L; ANC=1.5?10^9/L; PLT=80?10^9/L; Hb=90g/L; (6) Hepatic and renal function test: ALTAST=2.5 times that of the upper limit of normal; UreaCrea=1.25 times that of the upper limit of normal; (7) No known symptoms of heart failure & respiratory function insufficiency; (8) No known previous malignant tumor history; (9) Good treatment compliance, no mental disorders; (10) Signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) During pregnancy or lactation; (2) Allergic to chemotherapy substances or allergic constitution; (3) With massive ascites; (4) Positive lung, brain, or other organs metastasis; (5) During therapeutic course of other anticancer drugs or radiotherapy; (6) Participating in other clinical trials, or less than 4 weeks since the accomplishment of previous chemotherapy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare the toxic effects and safety of the neoadjuvant Chemotherapy drugs in combination with US contrast agent under sonication with the neoadjuvant Chemotherapy drugs alone.;tumor size; | — |
Countries
China
Contacts
Public ContactZHENG LIU
Xinqiao Hospital, Third Military Medical University
Outcome results
None listed