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Effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive function in elderly patients after controlled hypotension shoulder arthroscopy

Effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive function in elderly patients after controlled hypotension shoulder arthroscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17010347
Enrollment
Unknown
Registered
2017-01-06
Start date
2013-05-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shoulder arthroscopy in elderly patients

Interventions

1:parecoxib sodium 40mg was intravenously administered at 15 minutes before the induction of anesthesia, and dexmedetomidine was intravenously infused at a dose of 0.5 µg/kg over 15 minutes, followed
2:parecoxib sodium 40mg was intravenously administered at 15 minutes before the induction of anesthesia, and dexmedetomidine was intravenously infused at a dose of 0.5 ug/kg over 15 minutes, followed

Sponsors

Second Affiliated Hospital, Jiaxing University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: From June 2013 to May 2016, patients who were undergoing elective shoulder arthroscopic, according with American Society of Anesthesiologists (ASA) grade I-III, and = 60 years old were selected for this study. All patients were not treated by blood transfusion during operation, the blood glucose was < 10 mmol/L, and the SpO2 was greater than 96%.

Exclusion criteria

Exclusion criteria: the patients refused to participate, patients with a history of neurological and psychiatric disorders, patients who take psychotropic drugs, patients with a history of alcohol abuse or drug dependence, patients who often use pain medications, patients who receive opioid and dexmedetomidine for allergies, patients with mini–mental status examination (MMSE) scores < 23, patients with chronic obstructive pulmonary disease, patients with a history of heart block or sinus bradycardia.

Design outcomes

Primary

MeasureTime frame
the occurrence of post-operative cognitive dysfunction during 7 days after surgery ;

Countries

China

Contacts

Public ContactJian Lu

Second Affiliated Hospital, Jiaxing University

ljp200681@163.com+86 13967303968

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026