Hip osteoarthritis and avascular necrosis of the femoral head, hip dysplasia,knee osteoarthritis,knee traumatic arthritis
Conditions
Interventions
intravenous remedial group:intravenous remedial application of TXA after using TXA three times intravenously
control group:No more application of TXA after using TXA 3 times intravenously
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
30 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients following primary total hip/knee arthroplasty due to osteoarthritis, hip dysplasia and ischemic necrosis of the femoral head; 2. Patinets without preoperative platelet and coagulation function dysfunction; 3. Preoperative double lower limb venous color Doppler ultrasound was not abnormal; 4. voluntarily participated in clinical trials and signed informed consent, good compliance of patients.
Exclusion criteria
Exclusion criteria: (1) Patinets with history of venous thromboembolism, pulmonary embolism, cerebral infarction, coronary heart disease; (2) Patients with coagulation disorders; (3) Anticoagulant drugs are being used; (4) Administration of NSAID for less than 1 weeks; (5) TXA allergy; (6) Severe liver and renal insufficiency; (7) Patients with high risk of thrombosis, including atrial fibrillation, cardiac pacemaker, and stent implantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hidden blood loss;Inflammatory index;D-Dimer;Fibrin degradation products; | — |
Secondary
| Measure | Time frame |
|---|---|
| The drop of hemoglobin;Allogeneic blood transfusion rate;Total blood loss;VAS;Limb swelling ratio;Joint mobility;Postoperative hospital stay;adverse event rate; | — |
Countries
China
Contacts
Public ContactFuxing Pei
West China Hospital, Sichuan University
Outcome results
None listed