Ulcerative Colitis
Conditions
Interventions
Treatment group :Fecal Microbiota Transplantation
Sponsors
Chinese PLA General Hosipital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. Established UC according to the Lennard-Jones criteria; 3. Refractory UC: Mayo Scores= 6 and Endoscopic Mayo scores 3; 4. Treatments with 5-aminosalicylic acid (=3g/d) for at least 8 weeks, disease remained active, meanwhile treatment with glucocorticoids using a dose amount to =40mg/d of prednisone for at least 3 weeks, disease remained active, but patients refuse to take immunosuppressive agents or can not tolerate immunosuppressive agents; 5. Ability to give informed consent; Willing and able to participate in the study requirements, including serial stool collection, survey completion and clinic visits; 6. Without any antibiotic, probiotics or prebiotics use within the last 4 weeks.
Exclusion criteria
Exclusion criteria: Proctitis; Have other intestinal diseases: for example: bowel obstruction, perforation and/or abscess; Concurrent Clostridium difficile infection or other known infection; Any antibiotic, probiotics or prebiotics use within the last 1 months; Taking any immunosuppressive agents within 8 weeks; Pregnancy, lactation or plan to conceive within 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mayo scores;Endoscopic Mayo score;remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reactions;laboratory indexes;The structural and quantity alterations of intestinal flora pre- and after fecal transplantation; | — |
Countries
China
Contacts
Public ContactYunsheng Yang
Chinese PLA General Hosipital
Outcome results
None listed