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Topical versus intravenous corticosteroids in primary total knee arthroplasty: a randomized controlled trial

Corticosteroids administration in primary total knee arthroplasty: a randomized controlled trial of single-dose topical versus intravenous administration

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-16010139
Enrollment
Unknown
Registered
2016-12-12
Start date
2016-12-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe osteoarthritis of knee

Interventions

topical administration group:topical administration of 10mg dexamethasone
intravenous administration group:intravenous administration of 10mg dexamethasone

Sponsors

Department of Orthopaedics, West China Hospit
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagosed as severe osteoarthritis of knee and plan to undergo TKA; 2. Aged 50-80 years old femal or male; 3. BMI 20-35 kg/m2; 4. American Society of Anesthesiologists degree I~III; 5. IL-1, IL-6, CRP, TNFare normal before operation.

Exclusion criteria

Exclusion criteria: (1) allergic to hydrocortisone; (2) have used adrenal cortical hormone in recent sit years; (3) have diabetes hypertension, hypotension, thrombotic disease with 6 month,myocardial infarction within 6 month; (4) poor compliance; (5) mental disease,glaucoma,et al.

Design outcomes

Primary

MeasureTime frame
NRS score;nausea and vomiting;IL-6,CRP;Complicatoins;hospital stays;—

Countries

China

Contacts

Public ContactPengde Kang

Department of Orthopaedics, West China Hospital

kangpd@163.com+86 28 85422426

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026