asthma
Conditions
Interventions
GroupA: BT treatment group:BT treatment +drugs
Group B: drugs treatment group:drugs
Sponsors
Shanghai 10th People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Severe persistent asthma patients, aged = 18 years, male or female; 2. The patients is consistent with 5-6 levels of the National Asthma Education and Prevention Program (NAEPP) Guideline; Patients with prominent symptoms despite the use of stable maintenance therapy (eg. high-dose ICS + LABA); Patients with fatal acute attack usually requiring critical first aid, even though stable in remission; Patients with poor efficacy or intolerant side effects of drug treatments; 3. Can tolerate bronchoscopy; FEV1 = 50-60% of predicted before bronchodilators; 4. If a former smoker, Quit smoking = 1 year, <10 package years; 5. voluntary participate the clinical research and sign on the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with implanted devices, such as pacemakers or nerve stimulators; 2. Patients allergic to the sedatives, anesthetics and other drugs used during bronchoscopy; 3. Patients who received the treatment previously; 4. Patients with the respiratory tract infection when included; Patients in the acute exacerbation of asthma or adjusted the oral dose of glucocorticoids in the past two weeks; 5. Patients with With coagulopathy or oral anticoagulant drugs; 6. Patients with severe cardiovascular disease, insulin-dependent diabetes mellitus, neoplasms, epilepsy, and other poor compliances intolerant to bronchoscopy; 7. Patient with any situations the researchers believe that is not eligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ACQ;AQLQ; | — |
Secondary
| Measure | Time frame |
|---|---|
| FeNO;PEF;FEV1;EC;lgE; | — |
Countries
China
Contacts
Public ContactXIAOLIAN SONG
Shanghai 10th People's Hospital
Outcome results
None listed