gastric cancer
Conditions
Interventions
test group:multimodal analgesia
Control:Tramadol PCIA for two days, then, Tramadol 100mg, tid, im
Sponsors
Nanjing General Hospital of Nanjing Military Region
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Requirements of informed consent and assent of participant, parent or legal guardian as applicable; 2. Patients with gastric cancer scheduled for laparoscopic radical gastrectomy under general anesthesia and between the age of 18 and 75 years old male and female; 3. ASA physical status I-III; 4. Participants can follow the drug doses and visit plan; 5. Participants without diseases consisting of severe infection, respiratory dysfunction can describe the symptom objectively and cooperate actively; 6. Patients not allergic to opioids, sulfas, parecoxib, non-steroidal drugs, acetaminophen, tramadol etc.; 7. Patients without ischemic heart disease, cerebrovascular disease and peripheral vascular disease; 8. Patients without coagulation dysfunction and severe liver and renal dysfunction; 9. Patients without a history of drug abuse; 10. Women without pregnancy and lactation, or participants without a pregnancy plan within a month after the test of the subjects (also including male participants); 11. Did not participating other study in past 3 months; 12. Patients without a history of peptic ulcer bleeding or perforation.
Exclusion criteria
Exclusion criteria: 1. Do not meet the inclusion criteria, or certified by a doctor that doesn't fit to participate in this project; 2. Refuse to participate in this project; 3. Patients allergic to opioids, sulfas, parecoxib, non-steroidal drugs, acetaminophen, tramadol etc.; 4. Patients with ischemic heart disease, cerebrovascular disease and peripheral vascular disease, or their cardiac function > II (NYHA) patients; 5. Patients with gastric cancer with distant metastasis; 6. Patients with severe liver and renal dysfunction (Child – Pugh= 10; creatinine clearance < 25 ml/min); 7. Patients with suspect or have a history of drug abuse; 8. Pregnancy and lactation women, or have a pregnancy plan within a month after the test of the subjects (also including male participants); 9. Sponsors or researchers directly involved in the testing or their family members 10. Patients with conversion, palliative resection, intraoperative blood loss more than 600 ml, operation time more than 6 hours; 11. Patients with chronic pain(VAS=3)or using opioids of NSAIDs before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS classification;number of remedial treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to first flatus;time to first off-bed activity;time and length of off-bed activity per day;time to first semi-liquid diet;postoperative length of stay;serum CRP level;serum IL-6 level; | — |
Countries
China
Contacts
Public ContactZhi-Wei JIANG
Nanjing General Hospital of Nanjing Military Region
Outcome results
None listed