Rhinitis
Conditions
Interventions
Allergic rhinitis treatment group:hydrogen rich saline
Allergic rhinitis in control group:Normal saline
Chronic nasosinusitis treatment group:hydrogen rich saline
Chronic nasosinusitis in control group:normal salin
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Subjects should be Chinese citizens aged 18-60 years old, male and female; 2. Subjects in the screening and baseline follow-up must be diagnosed as allergic rhinitis or chronic nasal sinusitis; 1) allergic rhinitis diagnostic criteria: (according to 2015 Tianjin diagnostic criteria for the diagnosis and treatment of allergic rhinitis guide, Chinese Journal of Otorhinolaryngology Head and neck surgery, 2016,51 (01): 6-24)), with nasal itching, sneezing, runny nose and nasal symptoms in 4 at least 3, and at least two symptoms the score of 2 points or 2 points; 2) Diagnostic criteria for chronic rhinosinusitis: (with chronic nasal sinusitis in Kunming 2012 - Guidelines for diagnosis and treatment, the Chinese Journal of Otorhinolaryngology Head and neck surgery, 2013,48 (02): 92-94)), according to the subjective standard for evaluation VAS standard table in the standard for evaluation of more than 5 points or more, can be recruited; 3. The subjects should be in good health, and had no disease which can influence the test pocess, or safety of the subjects; 4. Subjects should signed the informed consent, and were required to follow up the medication schedule; 5. Female subjects with fertility, in the screening of urine HCG must be negative.
Exclusion criteria
Exclusion criteria: 1. Patients with acute sinusitis and nasal acute infection; 2. In the screening or baseline follow-up, the subjects had any clinical abnormalities or ECG results and clinical significant abnormalities; 3. The clinical significance of cardiovascular, lung, kidney, liver, metabolic diseases, hematologic or neurological disease subjects, or subjects with impaired immune systems; 4. Subjects had upper respiratory tract infection. 5. Subjects with nasal septum deviation and need to be corrected for surgery; 6. Subjects participated in the test are members of the research team or the host party staff. 7. Patients with other nasal diseases as nasal vestibule inflammation and nasal tumor etc.; 8. Subjects have pregnant planning within 3 month; 9. Participated in other clinical drug trials in 3 months; 10. Researchers think the subjects should not be included in the test for other reason; 11. Subjects have use of the drug may affect the results of the test, and the withdrawal time is less than the prescribed time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| saccharin test (second);number of the inflammatory cel (One / field of vision);Symptoms and signs scores(score); | — |
Countries
China
Contacts
Public ContactYU Shaoqing
Shanghai Tongji Hospital
Outcome results
None listed