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The mechanism of OK-432 (Sapylin) in reducing seroma formation after axillary lymphadenectomy in breast cancer

OK-432 (Sapylin) reduces seroma formation after axillary lymphadenectomy in breast cancer and its mechanism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-16009720
Enrollment
Unknown
Registered
2016-11-03
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seroma formation after axillary lymphadenectomy in breast cancer

Interventions

A:On the third day, patients will receive 30 ml of the OK-432 mixture (5kU OK-432 and saline), which was irrigated into the axillary wound through the suction drains, and the suction drains were clipp
B:On the third day, patients in the group received 30 ml of the saline, which was irrigated into the axillary wound through the suction drains, and the suction drains were clipped. After three hours,

Sponsors

Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Women with histologically confirmed breast carcinoma who underwent lymphadenectomy or surgery were considered for enrolment in the present study.

Exclusion criteria

Exclusion criteria: Patients, who tested positive for a penicillin skin test, were submitted to neoadjuvant therapy, had hypertension or diabetes, or used anticoagulants were excluded from the current study.

Design outcomes

Primary

MeasureTime frame
Incience of seroma formation;The healing time;The drainage volume;The time of axillary drainage;The leukocyte count of venous blood;The leukocyte count of drainage-fluid;IL-1 in the drainage-fluid;IL-6 in the drainage-fluid;The level of fibrous protein in the drainage-fluid;

Secondary

MeasureTime frame
Volume of seroma;The times of the evacuative punctures;

Countries

China

Contacts

Public ContactGaosong Wu

Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

wugaosongtj@163.com+86 13471444606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026