psoriasis
Conditions
Interventions
acitretin capsules group:Acitretin Capsules 1 pills, twice a day
methotrexate:methotrexate 7.5 mg/w, and then 25mg/W
Acitretin plus methotrexate group:Acitretin Capsules 1 pills, twice a day.methotrexate 7.5 mg/w, and then 25mg/W.
blank group:none
Sponsors
the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Males and females aged between 18 and 75 years; (2) Mild psoriasis vulgaris defined by the following criteria: Body surface area (BSA)>10% at screening and baseline and PASI>7 at screening and baseline; (3) Provide written informed consent and Willing and able to comply with all aspects of the protocol.
Exclusion criteria
Exclusion criteria: 1. Other types of psoriasis than mild psoriasis vulgaris eg, guttate, pustular, erythodermic, etc; 2. Any clinically active skin diseases other than moderate to severe psoriasis vulgaris which might counter or influence the study aim; 3. Patients who used any of the following systemic treatments within 4 weeks before the Baseline visit eg: drugs for other studys, immuno-suppressive drugs, biologics; 4. Patients who used topical treatment within 2 weeks before the Baseline visit eg corticosteroids ultraviolet-light therapy including sunbathing , or liquor carbonis detergens; 5. Active infectious disease which was hard to control; 6. History of hepatitis B or hepatitis C, and advanced HIV infection; 7. Laboratory data such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood lipid profile was 1.5 times higher than the normal limits; 8. History of severe systemic disease or cancer; 9. Pregnant or lactating females or willing to pregnant in 2 years; 10. patients who has allergy of methotrexate and Acitretin any ingredient; 11. Any other situations not suitable for this study determined by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis Area and Severity Index ( PASI); | — |
Secondary
| Measure | Time frame |
|---|---|
| dermatology life quality index; | — |
Countries
China
Contacts
Public Contactxia yumin
the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University
Outcome results
None listed