oral leukoplakia
Conditions
Interventions
control:orally take retinoid acid, 1-2mg/Kg/day, for 3 months
experiment:topically using 20% ALA gel, after 2 hours, the lesion would be irradiated with laser of 630nm, 100Mw/cm2 or 100J/cm2
Sponsors
Ninth People's Hospital, School of Medicine Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18 to 75 years old; 2. Those who are on first clinical visit, with the clinical and pathological diagnosis of oral leukoplakia; 3. Those who have not received any laser therapy, cryotherapy, radiotherapy or chemotherapy; 4. Those who can tolerate the designed therapy; 5. Those who can read and understand the informed consent form and be willing to attending the trial; 6. Those who are diagnosed as stage III or stage IV in oral leukoplakia, with auto-fluorescence test, DNA image cytometry and pathology.
Exclusion criteria
Exclusion criteria: 1. Those who are pregnant or nursing; 2. Those who are diagnosed as other oral mucosal diseases, tumor or psychopath; 3. Those who have received laser therapy, cryotherapy, radiotherapy or chemotherapy; 4. Those who can not tolerate the designed treatmen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficiency; | — |
Countries
China
Contacts
Public ContactTang Guoyao
Ninth People's Hospital, School of Medicine Shanghai Jiao Tong University
Outcome results
None listed