neuromyelitis optica spectrum disorder
Conditions
Interventions
intervention group:regular drug combined with hUC-MSC
congtrol group:regular drug combined with placebo
Sponsors
Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged at least 18 years; 2. a new focal neurological deficits; 3. met diagnostic criteria of NMOSD; 4. normal liver and kidney function, blood cell, urine examination.
Exclusion criteria
Exclusion criteria: 1. abnormal expression or disturbance of consciousness,instable vital signs; 2. diabetes, hyperthyroidism and other endocrine disorders; 3. severe mental illness patients who cannot be cooperated; 4. patients with severe liver or kidney disease and severe systemic chronic wasting disease; 5. gastrointestinal or other bleeding disorder within a mongth; 6. history of myelodysplastic syndrome; 7. use of non steroidal anti-inflammatory drugs; 8. plaque decrease by using injection of heparin or low molecular weight heparin or heparin; 9. history of relative drug allergy; 10. history of important surgeries a week ago; 11. can not cooperate in clinical trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| recurrence frequency, EDSS score, numbers of lesion in MRI; | — |
Primary
| Measure | Time frame |
|---|---|
| First recurrence time; | — |
Countries
China
Contacts
Public ContactGUAN YANGTAI
Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed