Upper gastrointestinal functional gastrointestinal disorders
Conditions
Interventions
control group : Esomeprazole
Traditional Chinese medicine treatment group :xiangbin prescription
Integrated group:Esomeprazole+xiangbin prescription
Sponsors
Guangdong Province Hospital of Traditional Chinese Medical
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with non erosive gastroesophageal reflux diseases meet the Gastric prolapse and Diagnostic criteria; 2. The patients who had not been treated with the gastric prolapse in the first 2 weeks before manometry; 3. The patients not be treated by PPI or Prokinetic drugs in past one week before the trial; 4. Duration of the disease more than 6 months; 5. the patient easy to make sense the treatment protocol and cooperating with the doctors; 6. Aged 18-65 years old; 7. Signed informed consent and willingness to cooperate with inspectors.
Exclusion criteria
Exclusion criteria: 1. Complicated with the primary and secondary upper gastrointestinal tract and other organs, tissues and malignant lesions; 2. Complicated with digestive tract malformation or the patients had a Gastrointestinal surgery history; 3. Woman in the period of pregnant or lactating; 4. Patients complicated with serious mental illness; 5. Patients complicated with diabetes mellitus, hyperthyroidism, and connective tissue disease; 6. Complicated with severe heart, liver and kidney dysfunction, endocrine and hematopoietic system diseases; 7. Patients complicated with the severe primary smooth muscle disease that can not take care of themselves; 8. The patients who are currently attending or participating in other clinical studies in past one month; 9. The researchers considers who is not suitable for this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal Qality of Life Index;24 hours pH dynamic acid determination;Gastric antrum - pyloro duodenal manometry; | — |
Secondary
| Measure | Time frame |
|---|---|
| hamilton Anxiety Scale;Hamilton Depression Scale;Ghrelin;motilin;Corticotropin releasing hormone;Bradykinin; | — |
Countries
China
Contacts
Public ContactShang Wenfan
Guangdong Province Hospital of Traditional Chinese Medical
Outcome results
None listed