tuberculosis
Conditions
Interventions
poor response tuberculosis immunotherapy group:autologous DC immunotherapy and Anti-tuberculosis chemotherapy
poor response tuberculosis control group:Anti-tuberculosis chemotherapy
normal TB group:Anti-tuberculosis chemotherapy
Sponsors
Shanghai Public Health Clinical Center Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: cohort study: 1. First time treatment of tuberculosis, AFB positive, meet diagnostic criteria of Chinese TB guidelines; 2. Aged 18-65 years; 3. Have fixed address, can be followed up; 4. Written informed consent obtained. Randomized controlled trial: All above plus: Sputum AFB positive after 2 months Anti-TB chemotheraphy.
Exclusion criteria
Exclusion criteria: For cohort study and randomized study: 1. Do not meet Inclusion criteria; 2. Severe heart disease;severe malnutrition; immunosuppressive therapy; renal dysfunction; diabetes; 3. Severe side effect during TB treatment; 4. History of severe hypersensitivity/allergic shock; 5. Women during pregnancy and lactation; 6. Severe mental disease; 7. Any other situation that is considered not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sputum AFB conversion time; | — |
Secondary
| Measure | Time frame |
|---|---|
| immune activity of T cell; | — |
Countries
China
Contacts
Public ContactLu Shuihua
Shanghai Public Health Clinical Center Affiliated to Fudan University
Outcome results
None listed