cirrhosis with refractory ascites
Conditions
Interventions
Treatment group:Shuiguitie topical plus tolvaptan 15mg po
control group:Shuiguitie topical placebo plus tolvaptan 15mg po
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to be as the subject; 2. in line with diagnostic criteria of the refractory liver cirrhosis; 3. in line with Chinese medicine syndrome of edema from deficiency in the spleen or yang deficiency of the spleen and kidney; 4. To be aged 18 to 65 years old.
Exclusion criteria
Exclusion criteria: 1. cirrhosis with infection or ascites caused by malignant tumors; 2.suffered with upper gastrointestinal bleeding or hepatic encephalopathy in 2 weeks; 3. complication with severe diseases (i.e. cardiovascular, renal and hematopoietic system ), mental defects, or asthma; 4. total bilirubin = 50umol/L or chronic or acute liver failure (PTA = 40%, or total daily bilirubin increased = 17.1umol / L); 5. serum albumin less than 25g / L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ascites volume;Urine output;supine abdominal circumference maximum;weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chinese Medical Syndrome scores;liver function;Blood sodium;Urine sodium;creatinine clearance rate; | — |
Countries
China
Contacts
Public ContactZHU Junfeng
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed