Liver-Obstructive Jaundice
Conditions
Interventions
Treatment Group:ursodeoxycholic acid capsule, p.o.
Control Group:Plancebo
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Consensus obtained after introducing the study in detail; 2) Obstructive jaundice by tumor compression, serum total bilirubin level > 200 umol/L; 3) The external biliary drainage was established either by percutaneous transhepatic procedure; 4) No history of hepatolithiasis.
Exclusion criteria
Exclusion criteria: 1) Jaundice referred to other reasons than tumor obstruction, (PBS, cirrhosis, et al.); 2) Bile stones detected under ultrasonography; 3) Clinical evidences of cholangitis; 4) Clinical evidences of pancreatitis; 5) Unsatisfied, only small amount of bile outflow after external drainage established; 6) Uncompensated liver or kidney function, or other organ failure; 7) Other contraindications detected against UDCA therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Total Bilirubin Concentration;Serum Direct Bilirubin Concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum alanine aminotransferase;serum aspartate aminotransferase;Serum Creatinine;prothrombin time;3-year overall survival;3-year recurrence rates; | — |
Countries
China
Contacts
Public ContactYong Zeng
West China Hospital, Sichuan University
Outcome results
None listed