Osteoarthritis, Osteonecrosis of Femoral Head
Conditions
Interventions
A: single bolus of 20 mg/kg IV-TXA before skin incision
B:another bolus of 10 mg/kg (or 1 g) IV-TXA 3 hours later
C:another two bolus of 10 mg/kg (or 1 g) IV-TXA 3, 6 hours later
D:another four bolus of 10 mg/kg (or 1 g) IV-TXA 3, 6,9,12 hours later
Sponsors
West China Hospital, Sichuan university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients, aged 18 years or older, who were scheduled to have primary unilateral THA/TKA for osteoarthritis (OA) or ANFH were considered eligible for included in the trial.
Exclusion criteria
Exclusion criteria: Exclusion criteria for both groups included patients with anemia (<120 g/L for female, <130 g/L for male), cardiovascular problems (history of myocardial infraction, angina, and atrial fibrillation), cerebrovascular conditions (history of previous stroke), thromboembolic disorders (history of deep-vein thrombosis (DVT) or pulmonary embolism (PE)), clotting disorders, known allergy to TXA,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hidden blood loss;Hb drop;inflammatory index (CRP IL-6);fibrinolysis index (D-Dimer, FDP); | — |
Secondary
| Measure | Time frame |
|---|---|
| total blood loss;transfusion;VAS pain score;Range of motion;Length of hospital stay;swelling ratio; | — |
Countries
China
Contacts
Public ContactPei Fuxing
Department of Orthopaedic Surgery, West China Hospital, SIchuan University
Outcome results
None listed