bronchopulmonary dysplasia
Conditions
Interventions
Group A:A loading dose of caffeine (20mg/kg, 2ml of volume by IV) will be given within first 24 hours after birth followed by 10 mg/kg of daily maintain dose.
Group B:2 ml of normal saline within first 6 hours after birth. On the second day, the infant will be given a loading 2 ml dose of caffeine
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All preterm neonates less than 32 weeks gestational age who need respiratory support and admitted to neonatal intensive care units (NICUs) within 24 hours of age on both Shanghai First Maternal and Infant Hospital and Children's Hospital of Fudan University between September 1, 2016 and August 31, 2017.
Exclusion criteria
Exclusion criteria: The preterm neonates diagnosed perinatally with major congenital anomalies, neuromuscular disorder, metabolic diseases, severe gastroesophageal reflux, and early mortality (death on DOL 1-3) will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of BPD;Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Side effect of Caffeine; | — |
Countries
China
Contacts
Public ContactJiangqin Liu
Shanghai First Maternity and Infant Hospital
Outcome results
None listed