Alzheimer's disease
Conditions
Interventions
Group 1:Routine treatment + rTMS on middle lobes and frontal lobes
Group 2:Routine treatment + tDCS on middle lobes and frontal lobes
Group 3:Routine treatment + rTMS on frontal lobes and tDCS on middle lobes
Group 4:Routine treatment + rTMS on frontal lobes
Sponsors
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed as mild-to-moderate AD (according to the criteria of NINCDS-ADRDA, with MMSEscores=15, CDR scores=0.5-2) were enrolled in this study. All patients took medicine (such as donepezil) for more than 3 months before the recruitment. Patients aged more than 55 and the course of disease is more than 6 months. Insidious onset and symptoms gradually appear in a few months to several years, rather than suddenly happen within a few hours or days with early, significant episodic memory disorders. All patients sign informed consent.
Exclusion criteria
Exclusion criteria: (1) other diseases cause of dementia, such as vascular dementia and frontotemporal dementia (FTD), DLB, folic acid or vitamin B12 deficiency, syphilitic dementia, thyroid function is low, etc; (2) depression (HAMD scores=17) caused by the pseudo dementia patients; (3) other nervous system diseases, systemic diseases and poisoning caused by dementia patients; (4) has a history of mental illness, such as schizophrenia and affective disorder; (5) out of delirium, epilepsy; (6) has a history of alcoholism or psychiatric drug abuse; (7) Patients heart, blood vessels, lung, liver, kidney and other major body in the acute phase of disease; (8) stimulate locations with metal; (9) hearing and eyesight severe with abnormalities; (10) Pet-name ruby skull damage or loss, can't cooperate with treatment.Rule out diabetes, heart disease, cerebrovascular disease, obesity, cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| imaging assessment; | — |
Countries
China
Contacts
Public ContactXiaolin Huang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed