severe sepsis
Conditions
Interventions
control group:Normal saline+convention medicine (SSC 2012 guaidline)
experimental group:xinmailong injection+convention medicine (SSC 2012 guaidline)
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Diagnostic criteria for severe sepsis; (2) Syndrome of Yang Qi Deficiency and Blood Stasis Syndrome; (3) Older than 18 years old; (4) Informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with acute myocardial infarction; (2) Severe heart failure (LVEF less than 30% or IV grade of heart function); (3) Patients with severe sepsis of other syndromes, such as excess syndrome and yin deficiency syndrome etc.; (4) Patients with severe bleeding tendency or active bleeding; (5) Allergic or allergic skin test in patients with the effect of drugs; (6) Patients who could not cooperate with the study and who had died within ICU24 hours, as well as the expected short period of death (12 points; (7) Renal insufficiency, Cr > 300, or need emergency CRRT; (8) Liver dysfunction, total bilirubin >100umol/L; (9) Pregnant and lactating women; (10) Mental or legal disability; (11) Clinical trials of other drugs in the first 3 months of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sepsis induced myocardiac dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| LVEF, CO, FS, LVEDD, E/A;HR, MAP, CVP;Lac, ScvO2, Pv-aCO2;BNP, cTnI;28 day mortality;SOFA score; | — |
Countries
China
Contacts
Public ContactGuo Liheng
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed