depression disorder
Conditions
Interventions
ketamine:single-dose i.v. ketamine (0.5mg/kg, 40 minutes)+ venlafaxine (150 mg/day, 4weeks)
control group:single-dose i.v. midazolam (0.045 mg/kg, 40 minutes) + venlafaxine (150 mg/day, 4weeks)
Sponsors
Beijing Chaoyang Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 25-64 years; 2. diagnosis of non-psychotic major depression established by treating psychiatrists and confirmed by a checklist based on DSM-IV criteria at study entry; 3. total score of the 17-item Hamilton Rating Scale for Depression (HAMD)–Chinese version =24 and a score of the item 3 on suicide risk =1; 4. ability to communicate and provide written consent.
Exclusion criteria
Exclusion criteria: 1. lifetime history of drug/alcohol dependence, psychotic, bipolar or obsessive-compulsive disorders; 2. any Axis I disorder other than major depression judged to be the primary presenting problem; 3. history of inefficacy or intolerance to venlafaxine; 4. Pregnant or breast-feeding; 5. suicide attempt in the current episode; 6. major medical conditions contraindicating the use of ketamine or midazolam or venlafaxine; or 7. ECT or NMDA antagonist medications administered within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg depression rating scale;16-item Quick Inventory of Depressive Symptomatology Self-Report;The Columbia-Suicide Severity Rating Scale; | — |
Countries
China
Contacts
Public ContactYongdong Hu
Beijing Chaoyang Hospital
Outcome results
None listed