Chronic kidney disease
Conditions
Interventions
intervention:drug
control group:no intervention
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. According to the chronic kidney disease (CKD) diagnostic criteria of 2012 KDIGO; 2. Male and Female; 3. Aged 20-75 years old; 4. CKD 3b-4: eGFR 15~45 mL/min/1.73m2; 5. No history of gout; 6. Serum uric acid =6.5 mg/dL; 7. No history of gastrointestinal disease, can take the lowering uric acid drug.
Exclusion criteria
Exclusion criteria: 1. Acute kidney disease, nephrotic syndrom, obstructive nephropathy, and other unstable patients; 2. Have taken the hemodialysis, peritoneal dialysis or kidney transplantation; 3. Pregnancy or nursing during the study; 4. Maligant tumor; 5. Hypersensitivity to Febuxostat; 6. Intake mercaptopurine, azathioprine; 7. Intake following drugs before the trial within 4 weeks: Febuxostat, allopurinol, benzbromarone, probenecid, uricase; 8. Intake within 4 weeks: losartan, fenofibrate, diuretics; 9. Hormone replacement with estrogens; 10. Undertake other clinical trial within three months; 11. Other unsuitable reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glomerular filtration rate; | — |
Countries
China
Contacts
Public ContactChang Wenxiu
Tianjin First Central Hospital
Outcome results
None listed