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Tranexamic acid administration in primary total knee arthroplasty: intravenous combined with topical vs. intravenous vs. topical?

Tranexamic acid administration in primary total knee arthroplasty: intravenous combined with topical vs. intravenous vs. topical?

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-16008801
Enrollment
Unknown
Registered
2016-07-07
Start date
2014-10-06
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

A:intravenous (15mg/kg, at 3 hours postoperatively 15mg/kg) combined with topical (2500mg+epinephrine)
B:intravenous (15mg/kg, at 3 hours postoperatively 15mg/kg)
C:topical (2500mg+epinephrine)use tranexamic acid

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: All patients undergoing primary total knee arthroplasty during study period

Exclusion criteria

Exclusion criteria: allergy to tranexamic acid; preoperative hepatic or renal dysfunction; preoperative use of anticoagular medication seven days prior to surgery; history of fibrinolytic disorder or blood dyscrasia; cerebrovascular accident, myocardial infarction, New York heart association class III or IV heart failure, atrial fibrillation, history of deep vein thrombosis or pulmonary embolus, preoperative INR >1.4, aPTT >1.4 x normal, platelets <140000/mm3.

Design outcomes

Primary

MeasureTime frame
knee function evaluation;haemoglobin level;perioperative complications: deep vein thrombosis;Blood loss;Hct;—

Secondary

MeasureTime frame
hospitalization expense;X-ray radiograph;Transfusion;ESR, CRP, IL-6;—

Countries

China

Contacts

Public ContactZhou Zongke

West China Hospital, Sichuan University

zongke@126.com+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026