osteoarthritis
Conditions
Interventions
Group A:tourniquet+20 mg/kg IV-TXA was administered 5-10 minutes before skin incision and 10mg/kg TXA was administered 3, 6, 12 and 24 hours later
Group B:20 mg/kg IV-TXA was administered 5-10 minutes before skin incision and 10mg/kg TXA was administered 3, 6, 12 and 24 hours later
Group C:only use tourniquet during the surgery
Sponsors
West China Hospital, Sichuan university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients, aged 18 years and older, who were scheduled for a primary TKA because of the end-staged osteoarthritis
Exclusion criteria
Exclusion criteria: Exclusion criteria included revisions, bilateral procedures, previous knee surgery history, flexion deformity=30 degree, varus/valgus deformity=30 degree, anemia (<120 g/L for female, <130 g/L for male), contraindications for the use of TXA and coagulation disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hidden blood loss;Maximum Hb change;CRP;IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| lower limb swelling ratio;VAS pain score;the length of hospital stays;transfusion rate;patient satisfaction;complications; | — |
Countries
China
Contacts
Public ContactFuxing Pei
West China Hospital, SiChuan University
Outcome results
None listed