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establish and verify the process of LMA preventing the complication of one lung ventilation

lung injurey of one lung ventilation during lung isolation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-16008752
Enrollment
Unknown
Registered
2016-06-30
Start date
2016-06-30
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute lung injury

Interventions

control:none
OLV preconditioning with FiO2 0.6:begin three episodes of OLV for 1 min and then two lung ventilation for 1min when draping
protective reinflation after OLV:following 5 episodes of mechanical ventilation with tidal volume of 10 ml/kg and respiratory rate of 12bpm when two lung ventilation, then manual reinflation
postoperative reinflation in PACU:guiding the patients how to blow the balloon 30min after extubation in PACU
OLV preconditioning+protective reinflation after OLV:1+2
OLV preconditioning+postoperative reinflation in PACU:1+3
protective reinflation after OLV+postoperative reinflation in PACU:2+3
OLV preconditioning+protective reinflation after OLV+postoperative reinflation in PACU:1+2+3
OLV preconditioning with LMA+protective reinflation after OLV+postoperative reinflation in PACU:after inserting LMA, 1+2+3

Sponsors

Nanfang Hospital of Southen Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. ASA grade I or II; 2. Aged from 18 to 65 years; 3. Body Mass Index 18~26 kg/m2.

Exclusion criteria

Exclusion criteria: 1. preoperative anemia: hemoglobin37.5 degree C at the 1st preoperative day; 3. FVC, FEV1, MVV<80% of prediced value; 4. history of asthma or airway hyperresponsiveness; 5. history of thoracic surgery; 6. preoperative pulmonary infection, COPD of bronchiectasis; 7. heart failure; 8. congenital heart disease; 9. coronary atherosclerotic cardiopathy; 10. Wolff-Parkinson-White syndrome; 11. disease of central nervous system; 12. history of strok; 13. hyperthyroidism or hypothyroidism; 14. myasthenia gravis; 15. diabetes; 16. hypoheptia; 17. hepatic carcinoma or hepatic metastasis; 18. chronic renal insufficiency; 19. allergic history of anesthetics; 20. family history of malignant hyperthermia; 21. drug abuse or alcohol dependence; 22. difficult airway; 23. history of radiotherapy or chemotherapy; 24. pregnancy or puerperium.

Design outcomes

Primary

MeasureTime frame
oxygenation index;TNF-a;IL-6;proBNP;saturation of pulse oximetry;—

Secondary

MeasureTime frame
heart rate;arterial blood pressure;peak airway pressure;bispectal index;temperature;—

Countries

China

Contacts

Public ContactYe Jing

Nanfang Hospital of Southen Medical University

w1605@163.com+86 18922363868

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026