Cardiac Surgery
Conditions
Interventions
Two groups:thromboelastography-guided transfusion algorithm versus standard clinical practice
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing single or multiple valve replacement with or without CABG; all subjects required cardiopulmonary bypass. All study subjects should be capable to provide informed consent.
Exclusion criteria
Exclusion criteria: Haemodynamically unstable requiring inotropes and intra-aortic balloon pump, Active malignancy, Bleeding diathesis, preexsisiting platelet count 325mg per day, Use of clopidogrel within 5 days, Recent treatment with glycoprotein IIbIIIa antagonist within 5days, Liver disease with raised liver enzyme, Renal dysfunction Cr >2mg/dL or>177 mmol/L, Resternotomy case.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative mediastinal chest tube drainage as an indicator of blood loss;Number (and proportion) of patients receiving packed red blood cells (PRBC), fresh frozen plasma (FFP), platelets and cryoprecipitate;Number of packs of PRBC, FFP, platelets and cryoprecipitate transfused; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative respiratory complications, including acute respiratory distress, Time to extubation, Renal dysfunction, Length of ICU stay, Surgical re-exploration, Early mortality within 48 hours after the operation.; | — |
Countries
China
Contacts
Public ContactTerence Luk
Department of Anaesthesia & Intensive Care, Prince of Wales Hospital
Outcome results
None listed