bronchial asthma
Conditions
Interventions
Group A:medication treatment only first, medication treatment+oxygen therapy later
Group B:medication treatment+oxygen therapy first, medication treatment later
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) BMI =28 kg/m2; 2) a diagnosis of bronchial asthma accoriding to GINA 2015; 3) regular use of ICS or ICS/LABA for at least 2 months; 4) ACQ score >=0.75.
Exclusion criteria
Exclusion criteria: All subjects should have no asthma exacerbation, respiratory tract infection or systemic corticosteroid use in the preceding 4 weeks, parenchymal lung disease apparent on chest radiography, respiratory failure, cardiovascular diseases, current smoking, pregnancy and lactation, autoimmune diseases, tumors, severe depression, plans for weight loss. Those who can not perform long-term domiciliary oxygen therapy in accordance with the study design.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma Control Questionnair score; | — |
Secondary
| Measure | Time frame |
|---|---|
| force vital capacity;forced expiratory volume in one second;sputum eosinophil percentage;sputum neutrophil percentage;sputum lymphocyte percentage;sputum macrophage percentage;serum leptin concentration;serum adiponectin concentration;serum IL-6 concentration;serum TNF-a concentration;Peak expiratory flow;FEV1/FVC;serum C-reactive protein concentration;serum 8-iso-prostaglandin F2a concentration;induced sputum 8-iso-prostaglandin F2a concentration;salbutamol dose;days free of asthma symtoms; | — |
Countries
China
Contacts
Public ContactHu Chengping
Huai'an Second People's Hospital
Outcome results
None listed