type 2 Diabetes Mellitus
Conditions
Interventions
Experimental group:Sancailianmei particle
The control group:acarbose
Sponsors
Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) At the age of 18-70; (2) In accordance with the diagnostic criteria of type 2 diabetes mellitus; (3) Body mass index in 18.5 kg/m2 to 30 kg/m2; (4) No drug history for treating Type 2 diabetes or Just received short-term (1 month) therapy and has been discontinued for 3 months before screening in the group; (5) poor blood sugar control after lifestyle intervention (HbA1c ranges7.0%-9.0%and FBG<=11.1mmol/L); (6) Not used antibiotics, micro ecological living bacteria preparation and lactulose before 4 weeks of visiting doctor (7) the patient who is Voluntary to participate in this study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) People with type 1 diabetes, Adult occult autoimmune diabetes, malignant tumor, or other autoimmune disease; (2) Gastrointestinal disease and (or) patients with periodontal disease; (3) Acute diabetes complications, including diabetic ketoacidosis, diabetes, high permeability of ketosis coma, hypoglycemia coma or severe unconsciousness hypoglycemia, etc.; (4) Severe gastrointestinal diseases, such as intestinal obstruction, intestinal ulcers or have obvious digestion, absorption, dysfunction of the patients; (5) Heart failure, unstable angina, severe arrhythmia, myocardial infarction occurred in 12 monthsSBP blood pressure > 180mmhg or DBP > 100mmhg; (6) History of liver disease such as cirrhosis of the liver, hepatitis B or hepatitis C (excluding carriers), or the AST and ALT 2.5 times higher than normal ceiling; (7) History of kidney disease or clinical diagnosis of renal insufficiency, serum creatinine greater than 1.5 mg/dl (including 132.6 mol/L); (8) With other endocrine system diseases, such as hyperthyroidism and disease of grow in quantity of cortisol; (9) suffering from severe trauma, severe infections, or surgery, as well as the treatment but not completely recovery; (10) people who have a mental illness, drug or other substance abuse or alcoholics; (11) people who are accepted Steroids or is being treated for a malignant tumor; (12) Allergies or allergic reactions to drugs used in this study; (13) Pregnancy, nursing mothers, childbearing age women not to take effective contraceptive measures, or plans to pregnancy during test, positive results of urine HCG test; (14) Participants take part in other drugs within three months; (15) Family members don't agree to participate in this test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting blood glucose;2-hour plasma glucose;glycosylated hemoglobin;oral glucose tolerance test;insulin releasing test;glucagon;glucagon-like peptide-1;intestinal flora; | — |
Countries
China
Contacts
Public ContactChenQiu
Chengdu University of TCM
Outcome results
None listed