Knee osteoarthritis
Conditions
Interventions
A:Synovectomy during the staged bilateral TKA
B:No synovectomy during the staged bilateral TKA
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
19 Years to 81 Years
Inclusion criteria
Inclusion criteria: 1. Primary unilateral total knee artropasty; 2. Patients with Knee osteoarthritis; 3. Aged from 20-80 years with no limitation of gender; 4. Patients who volunteered to participate in clinical trials and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients combined with acute trauma, tumor, severe osteoporosis, other autoimmune diseases and severe muscle contracture deformity around hip/knee; 2. Previous history of neuro-vascular injury, vasculitis and diabetic foot etc; 3. Related thrombosis history, such as pulmonary embolism, thrombosis and deep vein thrombosis in recent three months; 4. Coagulation disorders, bleeding tendency or intraoperative active bleeding; 5. Sever comorbidities in brain cardiovascular system, liver (ALT or AST > 2 high limitation of normal value), kidney (BUN > 1.5 high limitation of normal value or Cr > 1.5 high limitation of normal value), endocrine, nerve, hematopoietic system or consciousness disorders; 6. Pregnancy or breast-feeding; 7. Allergy to the test drug and human serum albumin, severe allergies, drug or alcohol depedence; 8. Participate in other clinical trials in recent three months; 9. The surgeons believe the patients not suitable for this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative inflammation (ESR; CRP; IL-6);drainage fluid inflammation (ESR; CRP; IL-6);Knee range of motion; | — |
Secondary
| Measure | Time frame |
|---|---|
| AKS;KOOS;SF-12;drainage fluid amount;Limb swelling;peri-temperature;Tension vesicle;Ecchymosis;Hb;Hit;albumin;operation time;postoperative blood loss; | — |
Countries
China
Contacts
Public ContactZhou Zong-ke
West China Hospital, Sichuan University
Outcome results
None listed