Hip/knee osteoarthritis
Conditions
Interventions
High-dose group:Dexamethasone administered 10 mg before surgery followed by 20 mg appropriate 4 hours after surgery
Multi-dose group:Dexamethasone administered 10 mg before surgery followed by 10 mg 4 h and 20 h after surgery
Low-dose group:Dexamethasone administered 10 mg before surgery followed by 10 mg 4 h after surgery
Sponsors
Department of Orthopaedics, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
22 Years to 72 Years
Inclusion criteria
Inclusion criteria: 1. Primary unilateral total knee artropasty; 2. Patients with Knee osteoartritis; 3. Able and willing to provide signed informed consent; 4. the level of IL-1, IL-6, CRP, TNF, ESR, NEUT are normal before surgery.
Exclusion criteria
Exclusion criteria: 1. Simultaneously bilateral total knee artropasty or revision case; 2. Surgical History of the knee joint; 3. Knee joint cavity paracentesis in recent 3 months; 4. Stiffness with knee; 5. Blood coagulation disorders; 6. History of deep venous thrombosis; 7. Concomitant medical problems such as uncontrolled hypertention, severe cardiovascular disorder, chronic obstructive pulmonary disease, liver or renal failure; 8. allergic to dexamethasone; 9. Using adrenal cortical hormone in recent sit months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS (0-100); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory indicators (ESR, CRP, IL-6);Blood transfusion volume;Blood transfusion cases;Hb;Hct;Length of hospital stay;Satisfaction;KOOS;Knee-extension strength;HOOS;5-scale musle score;HSS;KSS;Short-term Complications (SSI);Long-term Complications (Infection); | — |
Countries
China
Contacts
Public ContactZhou Zongke
Department of Orthopaedics, West China Hospital, Sichuan University
Outcome results
None listed