HBV-associated hepatocellular carcinoma
Conditions
Interventions
Anatomic resection group(AR):Anatomic resection
Nonanatomic resection group(NR):Nonanatomic resection
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patients age between 18 and 75 years,including male and female.Diagnosis of hepatocellular carcinoma for the first time; 2. HBsAg is positive; 3. Not beyond hemihepatic metastasis, In order to radical resection; 4. Liver function being Child-Pugh A.
Exclusion criteria
Exclusion criteria: 1. Severe systemic disease, can not tolerate hepatectomy; 2. The lesion is located in the caudate lobe; 3. Rupture of hepatocellular carcinoma; 4. Pathology is not primary hepatocellular carcinoma postoperation; 5. Patients with poor compliance; 6. Patients with extrahepatic and beyond hemihepatic metastases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood test indicators: 1. alpha-fetoprotein variant L3; 2. Interleukin 10; 3. Interleukin 12; 4. transforming growth factor ß.;Pathological examination indicators: 1. microvascular invasion; 2. carcinoma cell differentiation; 3. M1 macrophage; 4. M2 macrophage; 5. tumor size; 6. the number of tumor;Data related to the operation: 1. operation time; 2. time of vascular clamping; 3. intraoperative bleeding; 4. time of hepatectomy; 5. Intraoperative ultrasound results.;Postoperative complications: (1) wound infection; (2) hepatic cross section infection; (3) abdominal cavity hemorrhage; (4) liver failure; (5)bile leakage.;Postoperative recovery related data: 1. exhaust time; 2. feeding time; 3. Abdominal drainage time; 4. off-bed activity time; 5. postoperative hospital stay; 6. The total cost.;Postoperative follow-up: 1. Color Doppler ultrasound, Enhanced CT; 2. alpha-fetoprotein variant L3; 3. recurrence rate operation.; | — |
Countries
China
Contacts
Public ContactWentao Wang
Outcome results
None listed