severe aplastic anemia(SAA)
Conditions
Interventions
controlled arm:IST+ Chinese herbal simulants
treatment group:IST+ Chinese herbal granules
Sponsors
Zhejiang Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
14 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. meet the diagnosis of severe aplastic anemia, and the disease should be in the early phase of hemopoietic recovery; 2. patients from 14 years old to 80 years old; 3. not enrolled in other clinical trials; 4. No history of immunosuppressive therapy in past one month (for example, ATG/ALG +/- CsA or CsA).
Exclusion criteria
Exclusion criteria: 1. pancytopenia attributing to other disorders, such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, acute arrest of hemopoiesis, myelofibrosis and etc.; 2. patients candidate for hemopoietic stem cell transplantation; 3. severe comorbidities associated with heart, brain, liver and kidney or psychosis, or ECOG score >2 points; 4. women in pregnancy or breast feeding period; 5. patients unable to take, or allergy to Chinese herbal granules.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| general index;western medicine efficacy;Traditional Chinese Medicine efficacy;quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| immunoregulative index;telomerase activity of hemopoietic stem cells in bone marrow;gene expression of telomerase reverse transcriptase;TCR V-beta gene of bone marrow;serum VEGF level; | — |
Countries
China
Contacts
Public ContactYe Baodong, Zhou Yuhong
Outcome results
None listed