osteonecrosis of femoral head
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. The ages between 18-65 years old, sex is not limited; 2. To be expected to use a large dose of corticosteroids, the amount of the use of steroid in accordance with the following three: (1) cumulative prednisone dosage greater than 2000mg; (2) prednisone more than 30mg/ days, for a month or more; (3) the use of high dose glucocorticoid therapy (methylprednisolone over 160mg/ days, methylprednisolone for 3 days and above). 3. Be able to understand this research and sign the consent for this trial.
Exclusion criteria
Exclusion criteria: 1. the primary disease is serious , not suitable for the study; 2. in the former has been diagnosed with femoral head necrosis; 3. pregnant or lactating women; 4. allergic constitution and allergic to a variety of drugs; 5. patients with severe heart disease, cerebrovascular disease, liver and renal insufficiency (liver function tests ALT or AST exceed 2 times the upper limit of normal values, renal function test creatinine or urea nitrogen exceed the upper limit of normal values), hematopoietic system diseases, severe digestive tract diseases, mental and central nervous system diseases; 6. bleeding tendency; 7. is not suitable for magnetic resonance examination (lesiure disease, with cardiac pacemakers, metal ring etc.); 8. the researchers considered not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| occurence of osteonecrosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume of lesion; | — |
Countries
China