Postoperative Cognitive Dysfunction
Conditions
Interventions
Group C:an equal volume of normal saline
Group M1:After epidural injection, patients received continuous intravenous infusion of Methoxamedrine (2 mcg/kg/min)
Group M2:After epidural injection, patients received continuous intravenous infusion of Methoxamedrine (4 mcg/kg/min)
Group M3:After epidural injection, patients received continuous intravenous infusion of Methoxamedrine (6 mcg/kg/min)
Sponsors
the First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
75 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Over 75 years old; 2. American Society of Anesthesiology (ASA) II or III; 3. Mini-Mental State Examination (MMSE) score of > 23; 4. Greater than six years of education?Unilateral total hip replacement under epidural anesthesia.
Exclusion criteria
Exclusion criteria: 1. Deviant liver and kidney function; 2. There is an obvious history of neurological diseases or hyperthyroidism; 3. Taking sedative drugs, antidepressants or analgesics; 4. There is a history of drug abuse and alcohol abuse; 5. Obvious impairment of vision and hearing; 6. Electrolyte disturbance; 7. Pathoglycemia; 8. There is a clear infection or respiratory system complication before operation; 9. The second operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-alpha;MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP;CVP;HR;CO;SV;SpO2;The intraoperative total transfusion volume;The intraoperative dosage of ephedrine;The intraoperative and postoperative dosage of ropivacaine;The urine volume of 24 h after operation and in operation;The dosage of postoperative sufentanil ;The incidence of intraoperative pulmonary edema;The incidence of intraoperative hypertension;The incidence of intraoperative hypotension;The incidence of intraoperative tachycardia;The incidence of intraorative bradycardia;The cumulative time of intraorative hypotension;VAS score;BCS score; | — |
Countries
China
Contacts
Public ContactSun Defeng
Outcome results
None listed