Diminished Ovarian Reserve
Conditions
Interventions
Group 1 DOR patients treated with Melatonin plus DHEA supplementation (randomly allocation):Daily melatonin dosage is 4 mg capsule orally, take at 22:00–23:00 pm, in accordance with the studies of Tam
Group 2 DOR patients without treatment (randomly allocation):without treatment
Group 4 Normal Ovarian Reserve patients not randomly allocation:without treatment
Group 2 PCOS patients not randomly allocation:without treatment
Sponsors
Reproductive Medicine Institude, Xiangya First Hospital , Central South University
Eligibility
Sex/Gender
Female
Age
20 Years to 52 Years
Inclusion criteria
Inclusion criteria: For DOR patient: The criteria for DOR included AMH, FSH and Estradiol (E2) levels as well as antral follicle counts (AFC) or retrieved oocyte number. The patients were considered to have DOR if they have had serum AMH levels = 1 ng/ml or an AFC=5 on Day 3 of a spontaneous cycle or retrieved oocyte number =3. For NOR patient (Normal Ovarian Reserve): The criteria for Normal Ovarian Reserve (NOR) patients included AMH>3 ng/ml, FSH=10 IU/ml, an AFC=8 and or retrieved oocyte number =6. For PCOS patient: The criteria for PCOS patients included AMH>10 ng/ml, FSH/LH ratio >2, AFC for each ovaries = 12(Total = 25) and or retrieved oocyte number = 15 or clinical and/or biochemical signs of hyperandrogenism.
Exclusion criteria
Exclusion criteria: The patients with known conditions affecting ovarian reserve, including ovarian surgery, polycystic ovarian syndrome, endometriosis, post chemo and radiation therapy recovery or BMI = 25 will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryological outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical Outcomes; | — |
Countries
China
Contacts
Public ContactLi Yanping
Reproductive Medicine Institute, Xiangya First Hospital, Central South University
Outcome results
None listed