relapsed or refractory B acute lymphoblastic leukemia
Conditions
Sponsors
Hebei Yanda Ludaopei Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with relapsed leukemia during chemotherapy or with primary drug resistance leukemia who have been diagnosed as CD19+ B-cell acute lymphoblastic leukemia, or patients with hematologic relapse after drug withdrawal who can't achieve CR after 1 cycle of chemotherapy; 2. Aged 3 to 60 years; 3. Lymphoblast and prolymphocyte in blood <30% examined by morphology; 4. Patients or the clients authorized by patients sign the consent form,or pediatric patients' legal guardians sign the consent form and are voluntary to participate in the clinical trials.
Exclusion criteria
Exclusion criteria: Intracranial hypertension or unconsciousness; Symptomatic heart failure or severe cardiac arrhythmia; Respiratory failure; CD19 negative hematologic malignancy; Disseminated intravascular coagulation; Serum creatinine and/or urea nitrogen=1.5 ×normal;Sepsis or other uncontrolled active infection; Uncontrolled diabetes; Severe mental disorder; WHO physical status classification level=3; Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety;Ratio of bone marrow and peripheral B leukemia cells; | — |
Countries
China
Contacts
Public ContactChunrong Tong
Hebei Yanda Ludaopei Hospital
Outcome results
None listed