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Effect of Xiaoyu Xiezhuo Yin on Muscular Atrophy Induced by Chronic Renal Failure through IGF-1 / PI3K / Akt Signaling Pathway

Effect of Xiaoyu Xiezhuo Yin on Muscular Atrophy Induced by Chronic Renal Failure through IGF-1 / PI3K / Akt Signaling Pathway

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IIR-17013983
Enrollment
Unknown
Registered
2017-12-12
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease

Interventions

Traditional Chinese Medicine:Based on Western medicine treatment, add Xiaoyu Xiezhuo drink.
Western medicine:Only Western medicine treatment

Sponsors

Zhejiang Provincial Hospital of TCM
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. According with diagnostic criteria of chronic kidney disease CKD3-5; 2. According with diagnostic criteria of TCM syndromes; 3. Patients aged 18-75 years of age, gender is not limited; 4. Infection, acidosis, electrolyte imbalance and hypertension are better controlled; 5. No other organ failure; 6. Did not participate in other clinical trials in past six months,informed and willing to accept clinical research.

Exclusion criteria

Exclusion criteria: 1. For those who have known allergy to the study drug; 2. Had diagnosed as acute renal failure patients,hemodialysis or peritoneal dialysis patients; 3. Other organ function severely impaired; 4. Patients with consumptive diseases such as malignant tumor or active tuberculosis; 5. Patients with gastrointestinal bleeding or need to take other types of Chinese medicine during the test period; 6. Recent surgery history; 7. Pregnant and lactating women; 8. Researchers think it is inappropriate to participate in clinical trials

Design outcomes

Primary

MeasureTime frame
IGF-1;Scr;BUN;ALB;8-oxodG;SOD;eGSH-Px;

Secondary

MeasureTime frame
HB;Cho;Body Weight;

Countries

China

Contacts

Public ContactXia Hong

Zhejiang Chinese Medical University

xiahongaini@126.com+86 18368025950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026