Randomized-controlled trial evaluating the sequence of combined carbon-ion and photon radiotherapy for the treatment of nasopharyngeal carcinoma

Phase II randomized-controlled trial evaluating the sequence of combined carbon-ion and photon radiotherapy for the treatment of nasopharyngeal carcinoma

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IIR-17013303

Enrollment

Unknown

Registered

2017-11-08

Start date

2017-12-01

Completion date

Unknown

Last updated

2017-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasopharyngeal carcinoma

Interventions

1:Carbon-ion therapy followed by photon therapy

2:Photon therapy followed by carbon-ion therapy

Eligibility

Sex/Gender

All

Age

14 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Pathologically confirmed nasopharyngeal carcinoma, WHO grade II/III; 2. With measurable lesion before radiotherapy; 3. No distant metastasis; 4. Not previously irradiated; 5. Able to receive contrast MRI and/or CT scan; 6. Aged 14 - 80 year-old; 7. ECOG: 0-2; 8. Anticipated survival time >= 12 months; 9. With sufficient major organ functions; 10.Willing to sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Metal implants that might significantly influence the radiation dose distribution; 2. Dose constrains for organs-at-risk are beyond acceptable limit; 3. With comorbidities/conditions that might influence the effectiveness of carbon-ion therapy; 4. Pregnant or within lactation period; 5. Drug/alcohol addiction; 6. With mental disorder that might impede the completion of therapy.

Design outcomes

Primary

Measure	Time frame
Percentage of tumor shrinkage (log);	—

Secondary

Measure	Time frame
Progression-free survival;Toxicity;	—

Countries

China

Contacts

Public ContactJi-Yi Hu

Shanghai Proton and Heavy Ion Center

jiyi.hu@sphic.org.cn+86 18818000985

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026